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- Title
A classical setting for associations between markers and loci affecting quantitative traits.
- Authors
NIELSEN, DAHLIA M.; WEIR, B. S.
- Abstract
We examine the relationships between a genetic marker and a locus affecting a quantitative trait by decomposing the genetic effects of the marker locus into additive and dominance effects under a classical genetic model. We discuss the structure of the associations between the marker and the trait locus, paying attention to non-random union of gametes, multiple alleles at the marker and trait loci, and non-additivity of allelic effects at the trait locus. We consider that this greater-than-usual level of generality leads to additional insights, in a way reminiscent of Cockerham's decomposition of genetic variance into five terms: three terms in addition to the usual additive and dominance terms. Using our framework, we examine several common tests of association between a marker and a trait.
- Publication
Genetics Research, 1999, Vol 74, Issue 3, p271
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/s0016672399004231