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- Title
The Neural Representation of Interaural Time Differences in Gerbils Is Transformed from Midbrain to Cortex.
- Authors
Belliveau, Lucile A. C.; Lyamzin, Dmitry R.; Lesica, Nicholas A.
- Abstract
Interaural time differences (ITDs) are the dominant cue for the localization of low-frequency sounds. While much is known about the processing of ITDs in the auditory brainstem and midbrain, there have been relatively few studies of ITD processing in auditory cortex. In this study, we compared the neural representation of ITDs in the inferior colliculus (IC) and primary auditory cortex (Al) of gerbils. Our IC results were largely consistent with previous studies, with most cells responding maximally to ITDs that correspond to the contralateral edge of the physiological range. In Al, however, we found that preferred ITDs were distributed evenly throughout the physiological range without any contralateral bias. This difference in the distribution of preferred ITDs in IC and A1 had a major impact on the coding of ITDs at the population level: while a labeled-line decoder that considered the tuning of individual cells performed well on both IC and Al responses, a two-channel decoder based on the overall activity in each hemisphere performed poorly on Al responses relative to either labeled-line decoding of Al responses or two-channel decoding of IC responses. These results suggest that the neural representation of ITDs in gerbils is transformed from IC to Al and have important implications for how spatial location maybe combined with other acoustic features for the analysis of complex auditory scenes.
- Subjects
INTERAURAL time difference; MESENCEPHALON; AUDITORY cortex; NEURAL transmission; GERBILS as laboratory animals; INFERIOR colliculus; PHYSIOLOGY
- Publication
Journal of Neuroscience, 2014, Vol 34, Issue 50, p16796
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2432-14.2014