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- Title
Absence of mitochondrial malic enzyme in mice carrying two complementing lethal albino alleles.
- Authors
Eicher, Eva M.; Lewis, Susan E.; Turchin, Howard A.; Gluecksohn-Waelsch, Salome
- Abstract
Mitochondrial malic enzyme (MOD-2) was found to be missing in partially complementing genotypes between lethal deletion alleles at the albino locus in Chromosome 7 of the mouse. Since such partial complementers survive to adulthood, the absence of normal mitochondrial malic enzyme is compatible with life; however, the sterility of both females and males may be correlated with this enzyme deficiency. Of the six radiation-induced lethal albino mutations, five includedeletions for the Mod-2 locus mapping 1 centimorgan distally from c. Our data indicate that the maximum genetic distance occupied by any of these deletions is 6 centimorgans.
- Publication
Genetics Research, 1978, Vol 32, Issue 1, p1
- ISSN
0016-6723
- Publication type
Article
- DOI
10.1017/S0016672300018462