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- Title
Expansion of a liver-infiltrating cytotoxic T-lymphocyte clone in concert with the development of hepatitis-associated aplastic anaemia.
- Authors
Ikawa, Yasuhiro; Nishimura, Ryosei; Kuroda, Rie; Mase, Shintaro; Araki, Raita; Maeba, Hideaki; Wada, Taizo; Toma, Tomoko; Koizumi, Shoichi; Yachie, Akihiro
- Abstract
The article discusses the role of cytotoxic T-lymphocytes (CTLs) in bone marrow (BM) destruction in patients with aplastic anaemia (AA). It further discusses the correlation of oligoclonal expansion of CTLs with disease activity. It presents a case study of a one-year-old boy who was admitted to the hospital with complaints of acute liver failure and elevated bilirubin and transaminase levels.
- Subjects
T cells; BONE marrow diseases; ANEMIA; CASE studies; LIVER failure; BILIRUBIN; AMINOTRANSFERASES
- Publication
British Journal of Haematology, 2013, Vol 161, Issue 4, p599
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12259