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- Title
Iron‐Catalyzed Oxidative Hydroxyamination of Alkenes of Unsaturated Keto Oximes with TBHP as the Hydroxy Source.
- Authors
Tao, Li‐Ming; Yu, Li‐Mei; Xu, Jia‐Li; Kuang, Jie; Wang, Lu‐Bao; Li, Chuan‐Hua
- Abstract
A new iron‐catalyzed hydroxyamination of alkenyl ketoximes using TBHP as the hydroxy source to selectively assemble cyclic nitrones is described. Using inexpensive FeCl3 as the catalyst and TBHP as both the oxidant and hydroxy source, this reaction enables the formation of two new bonds, one C−N bond and one C−O bond, in a single reaction initiating from the oxime side through the nitrogen‐center radical geneation, radical addition across the C=C bond and radical hydroxylation cascades. This reaction has advantages of exquisite selectvity and excellent functional group tolerance, thus providing an economical and efficient strategy for the construction of complex heterocyclic compounds.
- Subjects
OXIMES; AMINATION; COMPLEX compounds; ALKENES; HETEROCYCLIC compounds; NITRONES; IRON chlorides
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 10, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200495