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- Title
DESFECHOS DA BERBERINA NA DISLIPIDEMIA: UMA REVISÃO SISTEMÁTICA.
- Authors
Francisco Soares, Iraíldo; da Silva Santos Oliveira, Amanda Suellenn; Lopes Macedo, Joyce; Alves de Lima, Michele; Alves da Silva, Robson
- Abstract
The aim of this systematic review is to demonstrate the results of published studies on the outcomes of berberine in dyslipidemia. Scientific articles published without time frame in the scientific databases PubMed, Scopus and EMBASE were investigated. The search was performed using the following descriptors from the Medical Subject Headings (MeSH), using Boolean operators: "Berberine" OR "Berberine Alkaloids" AND "Dyslipidemias" AND "Clinical Trial". The PICOS strategy (population, intervention, comparator, performance and type of study) defined the guiding question. The Cochrane Collaboration Tool was used to assess the risk of bias of the studies included in this review. The work followed PRISMA standards for its structuring. Among the articles that met the inclusion criteria, 05 most relevant studies were selected to compose this review. The results of the studies showed beneficial effects of berberine in decreasing VLDL-C, LDL-C, total cholesterol (TC) variations and increasing HDL-C levels. The role of berberine in decreasing lipid levels acts by increasing the expression of the hepatic LDL-associated cholesterol receptor (LDLR), acting in the regulation of the extracellular kinase (ERK) signal and also by increasing the transitional activity of the LDL promoter -R via the c-Jun transcription factor (JNK) kinase pathway. The results of this systematic review provide evidence of the benefits of berberine supplementation on dyslipidemias. However, new studies must be carried out to standardize the dose, time of ingestion and possible toxicity, so that its indication and supplementation reach safe levels.
- Subjects
COCHRANE Collaboration; BERBERINE; MEDICAL subject headings; SCIENCE databases; TRANSCRIPTION factors; LDL cholesterol; HDL cholesterol
- Publication
Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2021, Vol 15, Issue 96, p822
- ISSN
1981-9919
- Publication type
Article