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- Title
Research in Structural Modification of Biotransformation of Natural Drugs.
- Authors
He Ci-An; Yu Xu-Ya; Meng Qing-Xiong; Wang Ya-Ming
- Abstract
Biotransformation in structural modification of natural drugs is one of the effective ways for screening active compounds. According to the diversity and specificity of enzymes in biological systems and the selectivity and specificity characteristics of biotransformation with fewer by-products, this paper provide a systematic review on the common biotransformation methods in structural modification of natural medicine in recent years, such as hydroxylation, glycosylation, hydrolysis and epoxidation reactions, etc. Meanwhile, it also provides a review on the practical application of biotransformation in the development of new drugs and the change of activity of natural substances, such as changing the cytotoxic activity and enhancing anti-drug resistance, reducing toxicity or increasing bioavailability, etc.
- Subjects
BIOTRANSFORMATION (Metabolism); BIOLOGICAL systems; SYSTEMATIC reviews; ANTINEOPLASTIC agents; BIOAVAILABILITY; HYDROXYLATION; EPOXIDATION; GLYCOSYLATION
- Publication
Natural Product Research & Development, 2012, Vol 24, Issue 6, p843
- ISSN
1001-6880
- Publication type
Article