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- Title
Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids.
- Authors
Ma, Xiang; Liu, Lesen; Sun, Jing; Zhang, Yun; Liu, Yanqin; Liu, Miao; Wang, Bing; Chang, Yuna; Han, Yuling; Gai, Zhongtao
- Abstract
Background: The global spread of coronavirus disease 2019 (COVID‐19) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID‐19. Objective: To find the difference of angiotensin‐converting enzyme 2 (ACE2) in asthma and nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on its expression. Methods: The ACE2, immunoglobulin E (IgE), and eosinophils were tested in different children. Results: A total of 157 children aged 3–16 years were enrolled. The expression of ACE2 in asthma children were lower than nonasthma children (T = −2.512, p =.013). Allergic nonasthma children had a significant higher ACE2 expression than children with allergic asthma (p =.013) and nonallergic asthma (p =.029). The expression of ACE2 had no significant difference between first‐diagnosed asthma children and that had been treated with ICS for ≥6 months (F = 0.028, p =.598). The allergic asthma children showed a significantly higher eosinophils cells (EC) count than the allergic nonasthma (W = 200, p <.001) and nonallergic nonasthma children (W = 1089, p <.001). Nonallergic asthma children also had a significant higher EC count than the allergic non‐asthma (W = 182.5, p <.001) and nonallergic non‐asthma (W = 200.5, p <.001) children. There was no significant difference in IgE levels between asthmatic children and non‐asthmatic children (W = 2792.5, p =.18). Conclusion: Circulating ACE2 levels in asthmatic children were lower than those in non‐asthmatic children and ICS treatment for ≥6 months did not affect the expression of ACE2 in peripheral blood in the asthma children. Key Points: In the present study, we analyze the expression of circulating angiotensin‐converting enzyme 2 in asthmatic children and the effects of inhaled corticosteroids. And we found that the children with asthma had lower ACE2 level than no‐asthmatic children. Furthermore, there were no significant difference between the asthmatic children with or without ICS treatment. It's very helpful to get further understanding about the relationship between asthma and COVID‐19 in children.
- Subjects
ASTHMA in children; ANGIOTENSIN converting enzyme; WHEEZE; COVID-19 pandemic; COVID-19; ASTHMATICS
- Publication
Immunity, Inflammation & Disease, 2023, Vol 11, Issue 7, p1
- ISSN
2050-4527
- Publication type
Article
- DOI
10.1002/iid3.922