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- Title
Genetic polymorphism analysis of NAD(P)H: quinone oxidoreductase 1 in different Iranian ethnic groups.
- Authors
Biramijamal, Firouzeh; Sanati, Mohammed Hossein; Banoei, Mohammed Mahdi; Bayat, Behnaz; Arjmand, Sareh; Farhud, Daryoush
- Abstract
NAD(P)H: quinone oxidoreductase (NQO1) participates in the detoxification of numerous endogenous and foreign compounds. It has been shown that homozygous patients having T-allele exhibit negligible NQO1 enzyme activity. Lack of NQO1 activity might increase the risk of certain types of toxicity and cancer. It has been reported that this gene has a single nucleotide polymorphism at the site of codon 187 (nucleotide 609). It is indicated that NQO1 polymorphism has been associated with susceptibility to several malignancies. The frequency of NQO1 C609T polymorphism has not been reported among the Iranian population so far. We initiated a study to examine NQO1 C609T genotype in different Iranian ethnic groups. We assessed the genotype patterns of NQO1 among Iranian Fars, Mazandarani, Turk and Turkmen ethnic groups in eight regions. The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphisms analysis in 245 Iranian healthy individuals, 139 Fars (from five regions), 25 Mazandarani (from Babol), 42 Turk (from Urmia) and 39 Turkmen (from Bandar-Turkmen) ethnic groups. Their distributions for T-allele were similar to allele frequencies in Caucasians with the exception of the Mazandarani ethnic group (12%) and different from other Asians groups. Allele frequency of NQO1 C609T for Yazd population was significantly different from Shiraz, Mashhad and Mazandarani (P value = 0.015, 0.009, 0.029).
- Subjects
IRAN; GENETIC polymorphisms; METHYLENETETRAHYDROFOLATE reductase; NITROGUANIDINE; NAD (Coenzyme); ETHNIC groups
- Publication
Current Science (00113891), 2006, Vol 91, Issue 8, p1065
- ISSN
0011-3891
- Publication type
Article