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- Title
Effects of Stingless Bee Propolis on Experimental Asthma.
- Authors
de Farias, José Hidelbland Cavalcante; Silva Reis, Aramys; Rodrigues Araújo, Marcio Antonio; Araújo, Maria José Abigail Mendes; Martins Assunção, Anne Karine; de Farias, Jardel Cavalcante; Silva Fialho, Eder Magalhães; Silva, Lucilene Amorim; Costa, Graciomar Conceição; Guerra, Rosane Nassar Meireles; Ribeiro, Maria Nilce Sousa; do Nascimento, Flávia Raquel Fernandes
- Abstract
Bee products have been used empirically for centuries, especially for the treatment of respiratory diseases. The present study evaluated the effect of treatment with a propolis hydroalcoholic extract (PHE) produced by Scaptotrigona aff. postica stingless bee in a murine asthma model. BALB/c mice were immunized twice with ovalbumin (OVA) subcutaneously. After 14 days, they were intranasally challenged with OVA. Groups P50 and P200 received PHE by gavage at doses of 50 and 200mg/kg, respectively. The DEXA group was treated with intraperitoneal injection of dexamethasone.The OVA group received only water. The mice were treated daily for two weeks and then they were immunized a second time with intranasal OVA. The treatment with PHE decreased the cell number in the bronchoalveolar fluid (BAL). Histological analysis showed reduced peribronchovascular inflammation after treatment with PHE especially the infiltration of polymorphonuclear cells. In addition, the concentration of interferon-γ (IFN-γ) in the serum was decreased. These results were similar to those obtained with dexamethasone. Treatment with S. aff postica propolis reduced the pathology associated with murine asthma due an inhibition of inflammatory cells migration to the alveolar space and the systemic progression of the allergic inflammation.
- Subjects
DRUG therapy for asthma; ALBUMINS; ANALYSIS of variance; ANIMAL experimentation; BITES &; stings; BLOOD testing; BRONCHOALVEOLAR lavage; DRUG administration; INFLAMMATION; MICE; PERITONEUM; PHYSIOLOGIC salines; RESEARCH funding; STATISTICS; DATA analysis; EMPIRICAL research; DEXAMETHASONE; DATA analysis software; DESCRIPTIVE statistics; THERAPEUTICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2014, Vol 2014, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2014/951478