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- Title
Three-dimensional (3D) magnetic resonance volume assessment and loco-regional failure in anal cancer: early evaluation case-control study.
- Authors
Sekhar, Hema; Kochhar, Rohit; Carrington, Bernadette; Kaye, Thomas; Tolan, Damian; Saunders, Mark P.; Sperrin, Matthew; Sebag-Montefiore, David; van Herk, Marcel; Renehan, Andrew G.
- Abstract
<bold>Background: </bold>The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure compared with standard maximal tumour diameter (1D) assessment in patients with squamous cell carcinoma of the anus undergoing chemoradiotherapy.<bold>Methods: </bold>We performed an early evaluation case-control study at two UK centres (2007-2014) in 39 patients with loco-regional failure (cases), and 41 patients disease-free at 3 years (controls). mrTV was determined using the summation of areas method (Volsum). Reproducibility was assessed using intraclass concordance correlation (ICC) and Bland-Altman limits of agreements. We derived receiver operating curves using logistic regression models and expressed accuracy as area under the curve (ROCAUC).<bold>Results: </bold>The median time per patient for Volsum quantification was 7.00 (inter-quartile range, IQR: 0.57-12.48) minutes. Intra and inter-observer reproducibilities were generally good (ICCs from 0.79 to 0.89) but with wide limits of agreement (intra-observer: - 28 to 31%; inter-observer: - 28 to 46%). Median mrTVs were greater for cases (32.6 IQR: 21.5-53.1 cm3) than controls (9.9 IQR: 5.7-18.1 cm3, p < 0.0001). The ROCAUC for mrT-size predicting loco-regional failure was 0.74 (95% CI: 0.63-0.85) improving to 0.82 (95% CI: 0.72-0.92) when replaced with mrTV (test for ROC differences, p = 0.024).<bold>Conclusion: </bold>Preliminary results suggest that the replacement of mrTV for mrT-size improves prediction of loco-regional failure after chemoradiotherapy for squamous cell carcinoma of the anus. However, mrTV calculation is time consuming and variation in its reproducibility are drawbacks with the current technology.
- Subjects
UNITED Kingdom; MAGNETIC resonance; CASE-control method; SQUAMOUS cell carcinoma; FORECASTING; INTRACLASS correlation; ANAL cancer; RESEARCH; THREE-dimensional imaging; RESEARCH methodology; MAGNETIC resonance imaging; MEDICAL cooperation; EVALUATION research; ANAL tumors; COMPARATIVE studies
- Publication
BMC Cancer, 2020, Vol 20, Issue 1, pN.PAG
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-020-07613-7