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- Title
Circadian Rhythmicity by Autocatalysis.
- Authors
Mehra, Arun; Hong, Christian I.; Mi Shi; Loros, Jennifer J.; Dunlap, Jay C.; Ruoff, Peter
- Abstract
The temperature compensated in vitro oscillation of cyanobacterial KaiC phosphorylation, the first example of a thermodynamically closed system showing circadian rhythmicity, only involves the three Kai proteins (KaiA, KaiB, and KaiC) and ATP. In this paper, we describe a model in which the KaiA- and KaiB-assisted autocatalytic phosphorylation and dephosphorylation of KaiC are the source for circadian rhythmicity. This model, based upon autocatalysis instead of transcription-translation negative feedback, shows temperature-compensated circadian limit-cycle oscillations with KaiC phosphorylation profiles and has period lengths and rate constant values that are consistent with experimental observations.
- Subjects
PHOSPHORYLATION; CIRCADIAN rhythms; CYANOBACTERIA; OSCILLATIONS; GENETIC transcription
- Publication
PLoS Computational Biology, 2006, Vol 2, Issue 7, pe96
- ISSN
1553-734X
- Publication type
Article
- DOI
10.1371/journal.pcbi.0020096