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- Title
SIRT1 and miR-34a-5p: Valuable Biomarkers for the Early Detection of Cognitive Impairment in Type 2 Diabetes Mellitus.
- Authors
Vezza, Teresa; Víctor, Víctor M
- Abstract
A recent study published in the Journal of Clinical Endocrinology & Metabolism explores the potential of SIRT1 and miR-34a-5p as biomarkers for the early detection of cognitive impairment in patients with type 2 diabetes mellitus (T2DM). The study found that there is a notable reduction in mitochondrial function and decreased expression of SIRT1 in the peripheral blood mononuclear cells (PBMCs) of patients with Alzheimer's disease (AD) compared to healthy controls. Additionally, miR-34a-5p was found to be upregulated in the PBMCs of T2DM patients with cognitive impairment (T2DM-CI). The combination of SIRT1 mRNA and miR-34a-5p in PBMCs showed promise in accurately distinguishing T2DM-CI patients from T2DM patients without cognitive impairment. However, further research is needed to fully understand the role of miR-34a-5p in the development of cognitive impairment in T2DM.
- Subjects
TYPE 2 diabetes; SIRTUINS; COGNITION disorders; BIOMARKERS; REGULATION of body fluids; INSULIN receptors
- Publication
Journal of Clinical Endocrinology & Metabolism, 2024, Vol 109, Issue 7, pe1546
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgad740