We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A cost-effectiveness modeling study of treatment interventions for stage I to III esophageal squamous cell carcinoma.
- Authors
Daroudi, Rajabali; Nahvijou, Azin; Arab, Mohammad; Faramarzi, Ahmad; Kalaghchi, Bita; Sari, Ali Akbari; Javan-Noughabi, Javad
- Abstract
Background: Esophageal cancer causes considerable costs for health systems. Appropriate treatment options for patients with esophageal squamous cell carcinoma (ESCC) can reduce medical costs and provide more improved outcomes for health systems and patients. This study evaluates the cost-effectiveness of treatment interventions for patients with ESCC according to the Iranian health system. Material and methods: A five-state Markov model with a 15-year time horizon was performed to evaluate the cost-effectiveness of treatment interventions based on stage for ESCC patients. Costs ($US 2021) and outcomes were calculated from the Iranian health system, with a discount rate of 3%. One-way sensitivity analyses were performed to assess the potential effects of uncertain variables on the model results. Results: In stage I, the Endoscopic Mucosal Resection (EMR) treatment yielded the lowest total costs and highest total QALY for a total of $1473 per QALY, making it the dominant strategy compared with esophagectomy and EMR followed by ablation. In stages II and III, chemoradiotherapy (CRT) followed by surgery dominated esophagectomy. CRT followed by surgery was also cost-effective with an incremental cost-effectiveness ratio (ICER) of $2172.8 per QALY compared to CRT. Conclusion: From the Iranian health system's perspective, EMR was the dominant strategy versus esophagectomy and EMR followed by ablation for ESCC patients in stage I. The CRT followed by surgery was a cost-effective intervention compared to CRT and esophagectomy in stages II and III.
- Subjects
IRAN; TREATMENT of esophageal cancer; ENDOSCOPIC surgery; MEDICAL care costs; TUMOR classification; CHEMORADIOTHERAPY; COST effectiveness; QUALITY of life; STATISTICAL models; SQUAMOUS cell carcinoma; ESOPHAGEAL cancer; ENDOSCOPY; ABLATION techniques
- Publication
Cost Effectiveness & Resource Allocation, 2022, Vol 20, Issue 1, p1
- ISSN
1478-7547
- Publication type
Article
- DOI
10.1186/s12962-022-00352-5