We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Variant histology is associated with more non‐urothelial tract recurrence but less intravesical recurrence for upper tract urothelial carcinoma after radical nephroureterectomy.
- Authors
Yu, Tsung Yu; Wang, Hung Jen; Sung, Min Tse; Chuang, Yao Chi; Chen, Yen Ta; Cheng, Yuan Tso; Kang, Chih Hsiung; Liu, Hui Ying; Chang, Yin Lun; Luo, Hao Lun
- Abstract
Purpose: To investigate the prognostic impact of variant histology (VH) on oncological outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) who had undergone radical nephroureterectomy (RNU). Patients and methods: A total of 1239 patients with clinically localized UTUC who underwent RNU at a single institution between January 2005 and June 2020 were included. The VH was reviewed by a uro‐pathologist at our institution. The Cox regression model was used to perform multivariate analysis, including VH and other established prognostic factors for post‐RNU oncological outcomes (intravesical recurrence [IVR], non‐urothelial recurrence, and cancer‐specific death). Results: Of the 1239 patients with UTUC, 384 patients (31%) were found to have VH. Advanced tumor stage, lymph node metastasis, high tumor grade, lymphovascular invasion, open surgery, and renal pelvis had a significantly larger proportion of UTUC with VH compared to pure UTUC (all p < 0.05). VH was an independent prognostic factor associated with less IVR identified by multivariate analysis, more non‐urothelial recurrence, and more cancer‐specific mortality. Conclusion: Patients with VH account for 31% with UTUC treated with RNU in this cohort. VH was an independent prognostic factor associated with more non‐urothelial recurrence and cancer‐specific mortality but less IVR.
- Subjects
TRANSITIONAL cell carcinoma; INTRAVESICAL administration; KIDNEY pelvis; CANCER patients; URINARY organs; HISTOLOGY
- Publication
International Journal of Urology, 2024, Vol 31, Issue 4, p410
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/iju.15376