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- Title
Phenotypic heterogeneity of mycosis fungoides cells leads to the difficulties in determining tumour origin.
- Authors
Jin, Sha; Zhao, Yige; Wang, Shiwen; Wang, Panpan; Tang, Chenyu; Zhu, Mengyan; Wang, Ping
- Abstract
Mycosis fungoides (MF) is a low‐grade malignant cutaneous T‐cell lymphoma that originates from memory T cells. It typically follows a unique and relatively indolent disease course. MF is used to be characterized by a tissue‐resident memory T cell (TRM) phenotype, although recent molecular research has revealed its complexity, casting doubt on the cell of origin and the TRM‐MF paradigm. Recent clonal heterogeneity studies suggest that MF may originate from immature early precursor T cells. During development, the tumour microenvironment (TME) influences tumour cell phenotype. The exact origin and development trajectory of MF remains elusive. Clarifying the origin of MF cells is vital for accurate diagnosis and effective treatment.
- Subjects
MYCOSIS fungoides; IMMUNOLOGIC memory; TUMOR microenvironment; T cells; DISEASE progression
- Publication
Australasian Journal of Dermatology, 2024, Vol 65, Issue 5, pe114
- ISSN
0004-8380
- Publication type
Article
- DOI
10.1111/ajd.14304