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- Title
The effect of consolidation chemotherapy after concurrent chemoradiotherapy on the survival of patients with locally advanced non-small cell lung cancer: a meta-analysis.
- Authors
Wang, Xinshuai; Ding, Xuezhen; Kong, Dejiu; Zhang, Li; Guo, Yibo; Ren, Jing; Hu, Xiaochen; Yang, Junqiang; Gao, Shegan
- Abstract
Whether consolidation chemotherapy (CCT) after chemoradiotherapy (CRT) helps in the treatment of locally advanced non-small cell lung cancer (LA-NSCLC) is controversial. The aim of this meta-analysis was to evaluate the impact of CCT on overall survival (OS), progression-free survival (PFS), overall response rate (ORR) and toxicities in patients with inoperable LA-NSCLC. PubMed, Embase, The Cochrane Library, WanFang, VIP, and CNKI were searched to identify any relevant publications. After screening the literature and completing quality assessment and data extraction, the meta-analysis was performed using RevMan5.3 software. Ultimately, 5 eligible studies with a total of 1036 patients were selected for the present meta-analysis. The results of the analysis indicated that treatment of LA-NSCLC patients with CRT followed by CCT improved OS (pooled HR 0.85; 95% CI 0.73-0.99; P = 0.03), but did not improve PFS (pooled HR 0.78; 95% CI 0.60-1.02; P = 0.07) and ORR ( P = 0.26). Although it could increase the risk of grade ≥3 infection ( P = 0.04), it may not increase the risk of grade ≥3 radiation pneumonitis ( P = 0.09) during the CCT period. CCT after concurrent CRT may provide additional benefits in the treatment of LA-NSCLC. Although this therapeutic strategy did not prolong PFS, further assessment is warranted.
- Subjects
CANCER chemotherapy; CHEMORADIOTHERAPY; NON-small-cell lung carcinoma; PROGRESSION-free survival; RADIATION pneumonitis; CONSOLIDATION chemotherapy
- Publication
International Journal of Clinical Oncology, 2017, Vol 22, Issue 2, p229
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-016-1074-x