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- Title
Evaluation of postoperative chemotherapy in patients with uterine carcinosarcoma: a retrospective survey of the Tohoku Gynecologic Cancer Unit.
- Authors
Otsuki, Ai; Otsuki, Takeo; Tokunaga, Hideki; Niikura, Hitoshi; Nagase, Satoru; Sugiyama, Takashi; Toyoshima, Masafumi; Utsunomiya, Hiroki; Yokoyama, Yoshihito; Mizunuma, Hideki; Sato, Naoki; Terada, Yukihiro; Shoji, Tadahiro; Sugiyama, Toru; Nakahara, Kenji; Ohta, Tsuyoshi; Yamada, Hidekazu; Tase, Toru; Nishiyama, Hiroshi; Fujimori, Keiya
- Abstract
Background: The aim of this study was to evaluate prognostic factors including efficacy of postoperative chemotherapy in Japanese patients with uterine carcinosarcoma. Methods: We conducted a retrospective survey of seven medical facilities in the Tohoku Gynecologic Cancer Unit. Results: A total of 45 patients who had undergone hysterectomy and bilateral salpingo-oophorectomy were enrolled. No significant difference was observed in overall survival according to patient age (≤50 years vs >50 years) or retroperitoneal lymphadenectomy (performed vs. not performed). However, the International Federation of Gynecology and Obstetrics stage (stage I/II vs stage III/IV) and postoperative chemotherapy (provided vs not provided) were significant prognostic factors in both univariate and multivariate analyses for the 25-month median follow-up period. Conclusions: Our results revealed that postoperative chemotherapy should be considered for all uterine carcinosarcoma stages in Japanese patients.
- Subjects
UTERINE cancer; CARCINOSARCOMAS; POSTOPERATIVE period; CANCER chemotherapy; GYNECOLOGIC cancer; RETROSPECTIVE studies; CANCER treatment
- Publication
International Journal of Clinical Oncology, 2015, Vol 20, Issue 3, p574
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-014-0732-0