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- Title
Stem cells therapy in acute myocardial infarction: a new era?
- Authors
Carbone, R. G.; Monselise, A.; Bottino, G.; Negrini, S.; Puppo, F.
- Abstract
Stem cells transplantation after acute myocardial infarction (AMI) has been claimed to restore cardiac function. However, this therapy is still restricted to experimental studies and clinical trials. Early un-blinded studies suggested a benefit from stem cell therapy following AMI. More recent blinded randomized trials have produced mixed results and, notably, the last largest pan-European clinical trial showed the inconclusive results. Furthermore, mechanisms of potential benefit remain uncertain. This review analytically evaluates 34 blinded and un-blinded clinical trials comprising 3142 patients and is aimed to: (1) identify the pros and cons of stem cell therapy up to a 6-month follow-up after AMI comparing benefit or no effectiveness reported in clinical trials; (2) provide useful information for planning future clinical programs of cardiac stem cell therapy.
- Subjects
MYOCARDIAL infarction; STEM cell treatment; CLINICAL trial registries; STEM cell transplantation; HEART cells
- Publication
Clinical & Experimental Medicine, 2021, Vol 21, Issue 2, p231
- ISSN
1591-8890
- Publication type
Article
- DOI
10.1007/s10238-021-00682-3