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- Title
Sequence and functional expression of the GABA<sub>A</sub> receptor shows a ligand-gated receptor super-family.
- Authors
Schofield, Peter R.; Darlison, Mark G.; Fujita, Norihisa; Burt, David R.; Stephenson, F. Anne; Rodriguez, Henry; Rhee, Lucy M.; Ramachandran, J.; Reale, Vincenzina; Glencorse, Thora A.; Seeburg, Peter H.; Barnard, Eric A.
- Abstract
Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated α-subunit and β-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
- Publication
Nature, 1987, Vol 328, Issue 6127, p221
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/328221a0