We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
High-fat feeding rapidly induces obesity and lipid derangements in C57BL/6N mice.
- Authors
Podrini, Christine; Cambridge, Emma; Lelliott, Christopher; Carragher, Damian; Estabel, Jeanne; Gerdin, Anna-Karin; Karp, Natasha; Scudamore, Cheryl; Ramirez-Solis, Ramiro; White, Jacqueline
- Abstract
C57BL/6N (B6N) is becoming the standard background for genetic manipulation of the mouse genome. The B6N, whose genome is very closely related to the reference C57BL/6J genome, is versatile in a wide range of phenotyping and experimental settings and large repositories of B6N ES cells have been developed. Here, we present a series of studies showing the baseline characteristics of B6N fed a high-fat diet (HFD) for up to 12 weeks. We show that HFD-fed B6N mice show increased weight gain, fat mass, and hypercholesterolemia compared to control diet-fed mice. In addition, HFD-fed B6N mice display a rapid onset of lipid accumulation in the liver with both macro- and microvacuolation, which became more severe with increasing duration of HFD. Our results suggest that the B6N mouse strain is a versatile background for studying diet-induced metabolic syndrome and may also represent a model for early nonalcoholic fatty liver disease.
- Subjects
HIGH-fat diet; LABORATORY mice; OBESITY; PHYSIOLOGICAL effects of lipids; FATTY liver; METABOLIC syndrome
- Publication
Mammalian Genome, 2013, Vol 24, Issue 5/6, p240
- ISSN
0938-8990
- Publication type
Article
- DOI
10.1007/s00335-013-9456-0