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- Title
Development and Validation of a Sensitive Spectrofluorimetric Method for the Determination of Ibrutinib.
- Authors
Mondal, B.; Bali, A.
- Abstract
A reproducible, sensitive, and cost-effective spectrofluorimetric method has been developed for quantification of the drug ibrutinib in bulk and in its oral capsule formulation. The method was validated in accordance with the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use guidelines with respect to linearity, accuracy, precision, limit of detection (LOD), limit of quantification (LOQ), and robustness. The method was found to be extremely sensitive, and excellent linearity was noted within the concentration range 0.1–7.5 μg/mL with a correlation coefficient (r2) of 0.9961. The LOD and LOQ values for the proposed method were found to be 0.224 and 0.680 μg/mL, respectively. Excellent recoveries of the drug were observed from the marketed capsule formulation by the proposed method (97.59, 1.42% relative standard deviation).
- Subjects
DETECTION limit; STANDARD deviations; STATISTICAL correlation
- Publication
Journal of Applied Spectroscopy, 2022, Vol 89, Issue 2, p364
- ISSN
0021-9037
- Publication type
Article
- DOI
10.1007/s10812-022-01367-9