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- Title
Thymol reverses depression‐like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone‐induced depression model in female mice.
- Authors
Capibaribe, Victor Celso Cavalcanti; Vasconcelos Mallmann, Auriana Serra; Lopes, Iardja Stéfane; Oliveira, Iris Cristina Maia; Oliveira, Natalia Ferreira; Chaves, Raquell de Castro; Fernandes, Mariana Lima; Araujo, Mariana Albuquerque; Silva, Daniel Moreira Alves; Valentim, José Tiago; Maia Chaves Filho, Adriano José; Macêdo, Danielle Silveira; Vasconcelos, Silvânia Maria Mendes; Carvalho, Alyne Mara Rodrigues; Sousa, Francisca Cléa Florenço
- Abstract
Objectives: Based on this, the central therapeutic effects of thymol were verified in the neurotrophic pathway. Methods: Female swiss mice were divided into four groups: control, corticosterone (Cort), thymol (Cort + thymol) and fluvoxamine (Cort + Flu). The administration of corticosterone was used to induce depressive symptoms for 23 days. After the treatment, the animals were exposed the behavioural tests, such as forced swimming test, tail suspension test, sucrose preference test, light/dark test, social interaction test, Y‐maze test, plus‐maze test and hole‐board test. The hippocampus was also removed, and BDNF was measured by ELISA and Western blot. Key findings: As a result, thymol and fluvoxamine were able to reverse the depressive symptoms, as well as to improve the anxious frame. The anhedonic and short‐term memory was restored with the treatment. In the neurochemical tests, both thymol and fluvoxamine restored BDNF levels, improving the depressive condition. Conclusions: This work opens up new investigations aiming at the use of this molecule as a therapeutic alternative for treating depression disorders.
- Subjects
THYMOL; TREATMENT effectiveness; SHORT-term memory; MICE; WESTERN immunoblotting; SOCIAL interaction
- Publication
Journal of Pharmacy & Pharmacology, 2019, Vol 71, Issue 12, p1774
- ISSN
0022-3573
- Publication type
Article
- DOI
10.1111/jphp.13162