We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pharmacokinetics of linezolid in human non-inflamed vitreous after systemic administration.
- Authors
Juan P. Horcajada; Rebeka Atienza; María Sarasa; Dolors Soy; Alfredo Adán; Josep Mensa
- Abstract
Objectives To determine the concentration–time curves of linezolid in serum and vitreous from 24 patients undergoing vitrectomy. Methods Vitrectomy was performed 1, 2, 4, 8 and 12 h after infusion of 600 mg of linezolid in 20 patients divided into groups of four. Four additional patients were studied 12 h after two separate oral doses of 600 mg of linezolid. Serum samples were obtained 1 h after linezolid administration to determine Cmax; vitreous and a second serum sample were taken simultaneously during the vitrectomy in all patients, and the concentrations of linezolid in vitreous (Cv) and serum (Cs) were determined. Results Among patients who received one intravenous dose of 600 mg of linezolid, the highest mean Cv was observed at 4 and 8 h following linezolid administration (3.4 and 3.7 mg/L). The highest mean Cv was observed in patients who received two oral doses of 600 mg of linezolid separated by 12 h (4.5 mg/L), which was higher than the MIC90 for Staphylococcus epidermidis. The highest Cv/Cs ratio was reached 12 h after administration of one and two doses (2.4 and 1.5, respectively). Conclusions Microbiologically significant concentrations of linezolid can be achieved in the vitreous of the non-inflamed human eye after intravenous administration of 600 mg, and it is even better after two doses of 600 mg. It appears that linezolid accumulates in the vitreous, achieving potentially useful steady-state concentrations. An evaluation of clinical efficacy is needed to confirm the perceived utility based on the pharmacokinetics.
- Subjects
PHARMACOKINETICS; ANTIBIOTICS; VITREOUS body; DRUG administration; DIAGNOSTIC bacteriology; VITRECTOMY; INFUSION therapy; DRUG dosage
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2009, Vol 63, Issue 3, p550
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkn516