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- Title
miRAnno—network-based functional microRNA annotation.
- Authors
Tokar, Tomas; Pastrello, Chiara; Abovsky, Mark; Rahmati, Sara; Jurisica, Igor
- Abstract
Motivation Functional annotation is a common part of microRNA (miRNA)-related research, typically carried as pathway enrichment analysis of the selected miRNA targets. Here, we propose miRAnno, a fast and easy-to-use web application for miRNA annotation. Results miRAnno uses comprehensive molecular interaction network and random walks with restart to measure the association between miRNAs and individual pathways. Independent validation shows that miRAnno achieves higher signal-to-noise ratio compared to the standard enrichment analysis. Availability and implementation miRAnno is freely available at https://ophid.utoronto.ca/miRAnno/. Supplementary information Supplementary data are available at Bioinformatics online.
- Subjects
PROTEIN-protein interactions; MICRORNA; MOLECULAR interactions; WEB-based user interfaces; ANNOTATIONS; SIGNAL-to-noise ratio
- Publication
Bioinformatics, 2022, Vol 38, Issue 2, p592
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btab527