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- Title
The supportive use of photobiomodulation on salivary glands: a narrative review and meta-analysis.
- Authors
Oliveira, Susyane Vieira; Batista, João Victor Falcão; Gutierres, Gabriela Godinho; Silva, Nicole Pantojo; Lino-dos-Santos-Franco, Adriana; Rodrigues, Maria Fernanda Setúbal Destro; Cecatto, Rebeca Boltes
- Abstract
Purpose: Radiotherapy is one of the main strategies used in the treatment of cancer patients and it can cause early or late xerostomia and/or hyposalivation. Therapeutic management of xerostomia includes oral hygiene, sialogenic agents among others. Methods: This study reviews the use of extra-oral salivary glands photobiomodulation in treating xerostomia and/or hyposalivation after radiotherapy and performs a meta-analysis of this data. Results: After a broad search of the literature, eight clinical studies were selected. Discussion: In a safe way, the studies found that extra-oral stimulation of the salivary glands has benefits in the hyposalivation and changes in salivary flow resulting from lesions by radiotherapy. A meta-analysis found significant values in pain comparing the pre- and post-treatment moments (MD – 3.02, I2 95%, IC – 5.56; – 0.48) and for stimulated salivary flow at 30 days after the end of radiotherapy (MD 2.90, I2 95%, IC 1.96; 3.84). Conclusion: The most promising parameters comprise wavelengths between 630 and 830 nm, radiant exposure from 2 to 10 J/cm2, two-to-three times a week, before the radiotherapy damage, and homogeneously in the glands. Therefore, Light-Emitting Diode (LED) stimulation of larger areas than the punctual stimulation of small millimeters of the Low-Level Laser Therapy (LLLT) appears to be promising.
- Subjects
SALIVARY glands; PHOTOBIOMODULATION therapy; XEROSTOMIA; ORAL hygiene; LIGHT emitting diodes
- Publication
European Archives of Oto-Rhino-Laryngology, 2024, Vol 281, Issue 6, p2793
- ISSN
0937-4477
- Publication type
Article
- DOI
10.1007/s00405-023-08425-8