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- Title
Molecular biology: WHAMM!
- Abstract
The article highlights a research that addressed the importance of the protein called WHAMM. According to researchers, the protein helps transport other proteins within the compartments of the mammalian cells by interacting with two elements of the cell skeleton. Matthew Welch, Kenneth Campellone and their colleagues at the University of California, Berkeley, discovered that WHAMM intercedes in the transfer of proteins between the endoplasmic reticulum and the Golgi apparatus. Researchers traced distinct regions of the protein that interact with the membranes of the Golgi and with the two components of the cell's internal skeleton which are the actin and the microtubules, wherein these affects the amount of WHAMM in the human cells.
- Subjects
PROTEINS; CELL metabolism; CELL membranes; CELLULAR mechanics; REGULATION of cell growth; CELL communication; ENDOPLASMIC reticulum; GOLGI apparatus; CYTOLOGICAL research
- Publication
Nature, 2008, Vol 454, Issue 7203, p371
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/454371e