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- Title
Could the Lactate-Albumin Ratio be Successful in Predicting Mortality due to COVID-19 Infection?
- Authors
Genç, Ahmed Cihad; Toçoğlu, Aysel Gürkan
- Abstract
BACKGROUND/AIMS: High death rates are associated with coronavirus disease-2019 (COVID-19), particularly in severely ill hospitalized patients. Early detection of particularly severe cases will be beneficial for treatment decisions and clinical courses. Therefore, we aimed to discern the capacity of the lactate-albumin ratio (LAR) parameter in predicting the outcomes of patients admitted to the intensive care unit (ICU) to COVID-19 infection. MATERIALS AND METHODS: The study comprised 535 COVID-19-diagnosed patients who were admitted to the ICU. The data of the patients were obtained by retrospectively scanning the patient files. RESULTS: The study population consisted of 535 patients, 270 patients in the non-survival group and 265 patients in the survival group. In the non-survival group, the plasma lactate level was 2.3±1.4 mmol/L, whereas in the survival group, it was 1.74±0.8 mmol/L, and this difference was statistically significantly higher in the non-survival group (p<0.001). The plasma albumin level in the non-survival group was also 2.87±0.47 g/dL, whereas in the survival group, it was 3.36±0.55 g/dL. It was determined that this difference was statistically significant (p<0.001). The cut-off value of lactate in determining mortality in critically progressing COVID-19 patients was 1.725 [area under the curve (AUC): 0.637, %95 confidence interval (CI): 0.590-0.685] with 63% sensitivity and 60% specificity; albumin 3.03 (AUC: 0.763, 95% CI: 0.723-0.803) with 70% sensitivity and 66% specificity; and LAR 0.57 (AUC: 0.719, 95% CI: 0.676-0.763) with 68% sensitivity and 68% specificity. CONCLUSION: LAR can be safely used as a sepsis-related mortality marker in the ICU. However, although LAR is a successful indicator in patients hospitalized in the ICU because of COVID-19, it has yet to be as successful as it was in patients with sepsis. Its routine use may facilitate more information about LAR and patient decision-making.
- Subjects
ALBUMINS; INTENSIVE care units; COVID-19; RETROSPECTIVE studies; PATIENTS; HOSPITAL admission &; discharge; LACTATES; DESCRIPTIVE statistics
- Publication
Cyprus Journal of Medical Sciences, 2023, Vol 8, Issue 5, p339
- ISSN
2149-7893
- Publication type
Article
- DOI
10.4274/cjms.2023.2023-97