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- Title
Effects of Arbutin on Fatty Acid Levels of Erythrocyte and Serum in Wistar Albino Rats Treated with Potassium Bromate.
- Authors
Akkoyun, H. Turan; Aydın, Sevinç; Akkoyun, Mahire Bayramoglu; Bengü, Aydın Şükrü; Ekin, Suat; Erdem, Sinem Aslan
- Abstract
Background: In the presented study; the Effects of Arbutin (ARB) on the Rat Erythrocyte and serum fatty acid profile which is exposed to potassium bromate (KBrO3) were investigated. Materials and Methods: In this study, 32 Wistar albino rats weighing 250-300 g were used divided into 4 groups. Groups 1: control, group 2: KBrO3 (single dose 100 mg / kg gavage), group 3: ARB (50 mg / kg / day (ip) for 5 days), group 4: KBrO3 + ARB. At the end of the 5th day, alteration of fatty acid profile in erythrocyte and serum of rats in all groups was examined. Results: Rat serum essential fatty acid; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), erythrocyte major fatty acids; palmitic acid (C16:0), myristic acid (C14:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), arachidic acid (C20:0), eicosenoic acid (C20:1), and lignoceric acid (C24:0). In addition, in our studied serum and erythrocytes; Total monounsaturated fatty acids (MUFA) varied between 8.91 ± 0.53- 11.71 ± 2.55 and 33.71 ± 2.12- 37.11 ± 2.12, respectively. It was determined that total polyunsaturated fatty acids (PUFA) varied between 5.90 ± 1.29- 9.96 ± 1.18 and 14.72 ± 3.66-22.13 ± 4.82, respectively. Conclusion: In our study, alterations in fatty acid contents were observed, and results suggesting that arbutine affects the enzymes involved in Fatty acid metabolism and has an effect on fatty acid amounts.
- Subjects
FATTY acids; MONOUNSATURATED fatty acids; UNSATURATED fatty acids; EICOSANOIC acid; LABORATORY rats; PALMITIC acid; ESSENTIAL fatty acids
- Publication
Indian Journal of Pharmaceutical Education & Research, 2022, Vol 56, Issue 3, p740
- ISSN
0019-5464
- Publication type
Article
- DOI
10.5530/ijper.56.3.123