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- Title
Study of the Efficacy of PET/CT in Lung Aspiration Biopsy and Factors Associated with False-Negative Results.
- Authors
Il Wan Son; Ji Won Lee; Yeon Joo Jeong; Ahrong Kim; Hie Bum Suh; Geewon Lee
- Abstract
Purpose: We compared the outcomes of percutaneous transthoracic needle aspiration biopsy (PCNA) of lung masses in cases with and without prior positron emission tomography/ computed tomography (PET/CT) information, and investigated the factors associated with false-negative pathological results. Materials and Methods: From a total of 291 patients, 161 underwent PCNA without prior PET/CT imaging, while 130 underwent PET/CT before PCNA. Clinical characteristics, procedural variables, pathological results, and diagnostic success rates were compared between the 2 groups. Among patients with initial negative (non-specific benign) PCNA results, the radiological findings of these groups were compared to evaluate the predictors of false-negative lesions. Results: No significant difference was found in the clinical characteristics, procedural characteristics, and pathological results of the 2 groups, nor was the diagnostic rate significantly different between them (p = 0.818). Among patients with initial negative PCNA results, radiological characteristics were similar in both the groups. In multivariate analysis, the presence of necrosis (p = 0.005) and ground-glass opacity (GGO) (p = 0.011) were the significant characteristics that indicated an increased probability of initial false-negative results in PCNA. Conclusion: Routine PET/CT did not have any additional benefit in patients undergoing PCNA of lung masses. The presence of necrosis or GGO could indicate an increased probability of false-negative pathological results.
- Subjects
NEEDLE biopsy; POSITRON emission tomography; LUNG diseases; PATIENTS
- Publication
Journal of the Korean Society of Radiology, 2018, Vol 79, Issue 3, p129
- ISSN
1738-2637
- Publication type
Article
- DOI
10.3348/jksr.2018.79.3.129