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- Title
Aortic Pulse Pressure Is Associated With Carotid IMT in Chronic Kidney Disease: Report From Chronic Renal Insufficiency Cohort.
- Authors
DeLoach, Stephanie S.; Appel, Lawrence J.; Jing Chen; Joffe, Marshall M.; Gadegbeku, Crystal A.; Mohler III, Emile R.; Parsa, Afshin; Perumal, Kalyani; Rafey, Mohammed A.; Steigerwalt, Susan P.; Teal, Valerie; Townsend, Raymond R.; Rosas, Sylvia E.
- Abstract
BackgroundPatients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study.MethodsThree hundred and sixty-seven subjects with CKD enrolled in the CRIC study at the University of Pennsylvania site (mean age 59.9 years, blood pressure 129/74 mm Hg, estimated glomerular filtration rate 48 ml/min/1.73 m2, IMT 0.8 mm) had both carotid IMT and PWA measurements. Carotid ultrasound was also used to determine the presence of plaque. PWA was used to determine augmentation index (AI), amplification ratio (AMPR), aortic pulse pressure (C_PP), and central aortic systolic pressure (C_SP).ResultsIMT was significantly associated with all PWA-derived measures. However, on multivariable linear regression analysis, only AMPR (regression coefficient −0.072, P = 0.006), C_PP (regression coefficient 0.0025, P < 0.001), and C_SP (regression coefficient 0.0017, P < 0.001) remained significantly associated with IMT. The prevalence of carotid plaque in the cohort was 59%. Of the PWA-derived measures, only C_PP was significantly associated with the presence of carotid plaque (P < 0.001).ConclusionsPWA-derived measures are associated with carotid IMT and plaque in the CKD. Of these measures, C_PP was most associated with carotid IMT and plaque.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.156
- Subjects
UNITED States; CHRONIC kidney failure; KIDNEY diseases; CARDIOVASCULAR diseases; GLOMERULAR filtration rate
- Publication
American Journal of Hypertension, 2009, Vol 22, Issue 12, p1235
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1038/ajh.2009.156