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- Title
P-90: Soluble P-selectin, a marker of platelet activation, is related to plasma homocyst(e)ine in 'high risk' hypertensives.
- Authors
Spencer, Charles G.C; Martin, Steven C.; Felmeden, Dirk C.; Blann, Andrew D.; Beevers, Gareth; Lip, Gregory Y.H
- Abstract
Hyperhomocyst(e)inaemia has emerged as a risk factor for atherothrombotic disease. However, the mechanisms by which it acts are not fully elucidated. To examine the hypothesis that hyperhomocyst(e)inaemia might increase cardiovascular risk by causing a prothombotic state, we investigated the relationship between plasma homocyst(e)ine and haemorheological factors haematocrit, white blood count (WBC) and plasma viscosity (PV), the platelet activation marker soluble P-selectin (sP-sel) and the endothelial marker von Willebrand factor (vWF) in 165 hypertensives (mean age 63 (SD 8) years, 136 male) at high risk of cardiovascular disease as defined by the Framingham equation.Haemorheological factors and plasma markers were correlated with plasma homocyst(e)ine after natural logarithmic (log) transformation for non-normally distributed variables.Plasma sP-sel was strongly correlated with plasma homocyst(e)ine (p=0.007).In a stepwise linear regression analysis only smoking status, diastolic blood pressure, log sP-sel and log creatinine emerged as independent predictors of plasma homocyst(e)ine levels (R2=0.16, p=0.001).In conclusion, increased platelet activation as reflected by sP-sel may be one mechanism by which hyperhomocyst(e)inaemia confers an increased thrombotic risk in hypertension. (See Table)Am J Hypertens (2001) 14, 59A-59A; doi:S0895-7061(01)01629-6
- Publication
American Journal of Hypertension, 2001, Vol 14, p59A
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1016/S0895-7061(01)01629-6