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- Title
Invertebrate models of Alzheimer's disease.
- Authors
Link, C. D.
- Abstract
The intensely studied model organismsCaenorhabditis elegansandDrosophila melanogasterhave been employed to study a number of neurodegenerative diseases, including Alzheimer's disease (AD). Although worms and flies are phylogenetically distant from humans, results of both classic genetic analyses and transgenic manipulation of these invertebrates suggest they are valid models for at least some aspects of AD. This review describes the rationale for AD-relevant studies in worms and flies and discusses both what has been learned from these studies and what may be discovered in the future.
- Subjects
ALZHEIMER'S disease; CAENORHABDITIS elegans; DROSOPHILA melanogaster; DEMENTIA; BRAIN diseases
- Publication
Genes, Brain & Behavior, 2005, Vol 4, Issue 3, p147
- ISSN
1601-1848
- Publication type
Article
- DOI
10.1111/j.1601-183X.2004.00105.x