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- Title
The importance of repeated biopsies for the detection of T790M resistance mutation in non-small cell lung cancer – case report.
- Authors
Radu, Andreea Mihaela; Lupaşcu, Iulia Tatiana; Komporaly, Isabela Anda; Gheorghe, Adelina Silvana; Mateianu, Elena Adriana; Stănculeanu, Dana Lucia
- Abstract
T790M is a mutation of the epidermal growth factor receptor (EGFR), where the amino acid threonine is replaced by methionine at position 790 of exon 20. EGFR is a member of the receptor tyrosine-kinase family and has an important role in the development and progression of non-small cell lung cancer (NSCLC). The overexpression of EGFR may lead to cell proliferation, promotes angiogenesis, tumor invasion and metastasis, and also inhibits cell apoptosis. Acquired T790M mutation is the primary resistance mechanism to EGFR tyrosine kinase inhibitors (TKIs), used as first-line treatment in metastatic non-small cell lung cancer. We present the case of a 63-year-old woman with stage IV NSCLC, with EGFR exon 19 mutation, with TKI in first-line and multiples liquid biopsies performed at progression, who developed the T790M resistance mutation at more than three years after the diagnosis and received treatment with osimertinib.
- Subjects
NON-small-cell lung carcinoma; EPIDERMAL growth factor receptors; PROTEIN-tyrosine kinases; SOMATIC mutation; LYMPHATIC metastasis
- Publication
Oncolog-Hematolog, 2020, Issue 53, p7
- ISSN
2066-8716
- Publication type
Article
- DOI
10.26416/onhe.53.4.2020.4043