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- Title
Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review.
- Authors
Hanga-Farcaș, Alina; Miere, Florina; Filip, Gabriela Adriana; Clichici, Simona; Fritea, Luminita; Vicaș, Laura Grațiela; Marian, Eleonora; Pallag, Annamaria; Jurca, Tunde; Filip, Sanda Monica; Muresan, Mariana Eugenia
- Abstract
Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts); the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoprotegerin, osterix, RANKL, Runx2); and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds—such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others—presented a beneficial and stimulating effect in the bone regeneration process due to the pro-estrogenic activity, the antioxidant and the anti-inflammatory effect and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone-related pathologies envisaged through the incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.
- Subjects
BONE regeneration; PHYTOCHEMICALS; BONE cells; ORAL drug administration; BONE metabolism; CELLULAR signal transduction
- Publication
Plants (2223-7747), 2023, Vol 12, Issue 10, p2055
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants12102055