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- Title
Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances.
- Authors
Khantham, Chiranan; Linsaenkart, Pichchapa; Chaitep, Tanakarn; Jantrawut, Pensak; Chittasupho, Chuda; Rachtanapun, Pornchai; Jantanasakulwong, Kittisak; Phimolsiripol, Yuthana; Sommano, Sarana Rose; Prom-u-thai, Chanakan; Jamjod, Sansanee; Arjin, Chaiwat; Sringarm, Korawan; Berrada, Houda; Barba, Francisco J.; Carmona, Francisco David; Nimlamool, Wutigri; Ruksiriwanich, Warintorn
- Abstract
Androgenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-androgenic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflammation via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.
- Subjects
THAILAND; RICE bran; GENETIC regulation; RICE; BRAN; RICE hulls; BALDNESS; AGRICULTURAL wastes
- Publication
Plants (2223-7747), 2022, Vol 11, Issue 3, p330
- ISSN
2223-7747
- Publication type
Article
- DOI
10.3390/plants11030330