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- Title
Nociceptin Receptor Antagonism Modulates Electrophysiological Markers of Reward Learning.
- Authors
Iturra-Mena, Ann M; Kangas, Brian D; Pizzagalli, Diego A
- Abstract
Significance Statement Using in vivo electrophysiology and a reward-learning task reverse-translated from humans, this study tested the hypothesis that a nociceptin (NOP) receptor antagonist (J-113397) would potentiate behavioral and electrophysiological markers of reward learning in rats. A significant treatment × reward feedback × stimulus type interaction emerged for the ACC and post hoc tests further clarified that the interaction was driven by more positive deflection to nonrewarded lean trials for J-113397 than vehicle, albeit at a trend level (P =.059). Feedback-Locked 1-5 Hz (Delta) Frequency Band Compared with nonrewarded, rewarded trials elicited overall significantly higher delta power (200-600 milliseconds) in ACC and NAc (reward feedback: ACC: F SB [1,10] sb = 62.68; I P i <.0001; NAc: F SB [1,10] sb = 24.12; I P i =.001) (Figure 2A-D).
- Subjects
NOCICEPTIN; ELECTROPHYSIOLOGY; STIMULUS &; response (Psychology); BEHAVIORAL research
- Publication
International Journal of Neuropsychopharmacology, 2023, Issue 7, p496
- ISSN
1461-1457
- Publication type
Article
- DOI
10.1093/ijnp/pyad031