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- Title
Effects of Sodium Glucose Co-transporter 2 Inhibitors on Exercise Stress Test Parameters in Patients with Diabetes.
- Authors
KILIÇ, Mehmet Selman; BACAKSIZ, Ahmet
- Abstract
Introduction: This study aimed to evaluate the effects of sodium glucose co-transporter 2 inhibitors on exercise stress test parameters in patients with exaggerated blood pressure response (EBPR) during treadmill exercise stress tests. Method: This was a single-center, cross-sectional, observational study. The study included patients who underwent treadmill exercise stress test with a suspicion of coronary artery disease. Hypertensive response in treadmill stress test: In accordance with the Framingham criteria, systolic blood pressure at peak exercise is defined as =210 mmHg for men and =190 mmHg for women. The study included 58 patients with EBPR and 36 patients with normal blood pressure response as a control group with a similar age and gender. Results: Most of the patients were middle-aged (mean age 49.4±12.8 years) males (67 males, 68%). Of the patients, 54% had essential hypertension, 25 had coronary artery disease, and only 14% were diabetic. Patients with EBPR mostly had previously known essential hypertension (63%), coronary artery disease (58%), and smoking (53%). EBPR was most frequent in diabetics (85.7%) and was more common than in non-diabetics. Because only 4 of the diabetic patients used SGLT-2i, we could not evaluate the relationship between blood pressure response to exercise and SGLT-2i use in diabetic patients who underwent exercise stress testing. Conclusions: As expected, EBPR was detected more frequently in diabetic patients. We could not evaluate whether the use of SGLT-2i, which has a blood pressure-correcting effect, reduces EBPR because of the limited number of patients. We believe that we can conclude on this issue by expanding our study with diabetic patients using SGLT-2i.
- Subjects
SODIUM-glucose cotransporters; EXERCISE tests; TREADMILL exercise tests; SYSTOLIC blood pressure; PEOPLE with diabetes; CORONARY artery disease
- Publication
Bezmialem Science, 2024, Vol 13, pS81
- ISSN
2148-2373
- Publication type
Abstract