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- Title
Role of L-Type Calcium Channels in Increased Fatigue of the Rat Soleus Muscle under Functional Unloading.
- Authors
Sharlo, K. A.; Lvova, I. D.; Tyganov, S. A.; Sidorenko, D. A.; Shenkman, B. S.
- Abstract
Excessive long-term accumulation of calcium ions in the myoplasm of skeletal muscles can negatively affect mitochondria and lead to muscle dysfunction. The aim of our study was to identify the role of L-type calcium channels in the development of increased fatigue of the rat soleus muscle under functional unloading. Young male Wistar rats were divided into three groups of 8 animals each: vivarium control group (C), group exposed to 7-day hindlimb unloading (7HS), and group exposed to 7-day hindlimb unloading with daily intraperitoneal injections of nifedipine (7 mg/kg body weight) (7HS+N). Nifedipine administration during hindlimb unloading prevented the upregulation of calcium-dependent phosphorylation of calcium-calmodulin kinase II (CaMKII) and an increase in fatigue, as well as promoted the preservation of mitochondrial proteins, mtDNA, and mRNA expression of a number of regulatory genes of mitochondrial biogenesis in the rat soleus muscle.
- Subjects
SOLEUS muscle; CALCIUM channels; FATIGUE (Physiology); LOADING &; unloading; MITOCHONDRIAL proteins; REGULATOR genes; MUSCLE fatigue; CALMODULIN
- Publication
Journal of Evolutionary Biochemistry & Physiology, 2023, Vol 59, Issue 2, p620
- ISSN
0022-0930
- Publication type
Article
- DOI
10.1134/S0022093023020278