We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Small intestinal stromal tumors: A clinicopathologic study of 31 tumors.
- Authors
Mee Soo Chang; Gheeyoung Choe; Woo Ho Kim; Yong II Kim
- Abstract
The biologic behavior of gastrointestinal stromal tumors is difficult to predict, and they can be best studied in a site-specific fashion. The aims of this study are to analyze the clinicopathologic parameters and assess the prognostic value of p53 (DO-7) and Ki-67 (MIB-1) immunoreactivities in small intestinal stromal tumors (SIST). The histopathologic features of 31 SIST were assessed and categorized into two groups as follows. Group A (clinically aggressive) in which death due to tumor, metastasis, recurrence or relapsed melena were seen (n = 15) and group B (clinically benign; n = 16). For both groups, the period of follow-up was 30–144 months. p53 overexpression was observed in four tumors (31%) in group A, and in none in group B. For groups A and B, the mean Ki-67 index was 16.8 ± 12.5 and 8.4 ± 12.6, respectively. Statistical analysis revealed that the significant predictors of malignancy were high cellularity (odds ratio (OR) = 999; 95% confidence interval (Cl) = 0–999); p53 overexpression (OR = 999; Cl = 0–999); size of tumor ⩾ 5 cm (OR = 18.0; Cl = 1.9–171.9); ⩾ 5 mitoses/50 high-power fields (HPF)(OR = 17.1; Cl = 1.8–165.9); pleomorphism (OR = 17.1; Cl = 1.8–165.9); and necrosis (OR = 11.9; Cl = 2.2–65.1; P<0.05). High Ki-67 index (⩾8.4) had a marginal impact on risk (OR = 4.1; Cl = 0.8–20.2; P = 0.08). In conclusion, high cellularity, p53 overexpression, size of tumor ⩾ 5 cm, ⩾ 5 mitoses/50 HPF, pleomorphism and necrosis are important parameters for the prediction of malignancy in SIST.
- Subjects
GASTROINTESTINAL stromal tumors; SMALL intestine; P53 protein; PROGNOSIS; HISTOPATHOLOGY; TUMOR suppressor proteins; METASTASIS
- Publication
Pathology International, 1998, Vol 48, Issue 5, p341
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.1998.tb03916.x