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- Title
Resolving Volume-Restricted Metabolomics Using Sheathless Capillary Electrophoresis--Mass Spectrometry.
- Authors
Ramautar, Rawi
- Abstract
The analytical toolbox used in present-day metabolomics encounters difficulties for the analysis of limited amounts of biological samples. Therefore, a significant number of crucial biomedical and clinical questions cannot be addressed by the current metabolomics approach. Capillary electrophoresis--mass spectrometry (CE-MS) has shown considerable potential for the profiling of polar and charged metabolites in volume-restricted or mass-limited biological samples. This article considers advances that significantly improved the performance of CE--MS for in-depth metabolic profiling of limited sample amounts. Attention is also devoted to various technical aspects that still need to be addressed to make CE--MS a viable approach for volume-restricted metabolomics.
- Subjects
METABOLOMICS; CAPILLARY electrophoresis; MASS spectrometry; METABOLITES; ELECTROSPRAY ionization mass spectrometry
- Publication
LC-GC Europe, 2017, Vol 30, Issue 12, p658
- ISSN
1471-6577
- Publication type
Article