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- Title
HPLC Analysis of Non-volatile Analytes Using Charged Aerosol Detection.
- Authors
Gamache, Paul H.; McCarthy, Ryan S.; Freeto, Scott M.; Asa, Darwin J.; Woodcock, Matthew J.; Laws, Katherine; Cole, Roderic O.
- Abstract
A new detection method based upon aerosol charging was examined for its applicability and performance with high performance liquid chromatography (HPLC). Our results demonstrate universal detection of nonvolatile analytes with response magnitude that is independent of analyte chemical properties, four orders of magnitude dynamic range, low nanogram. lower limits of detection and < 2% relative standard deviation response variability. Broad applicability was demonstrated for a range of methods including those using gradient elution, reversed phase, hydrophilic interaction, and ion chromatography; normal and narrow bore column formats; and in combination with other detectors (for example, UV detectors, evaporative light-scattering detectors and mass spectrometers).
- Subjects
HIGH performance liquid chromatography; AEROSOLS; AIR pollution; DETECTORS; SPECTRUM analysis instruments; MASS spectrometers
- Publication
LC-GC Europe, 2005, Vol 18, Issue 6, p345
- ISSN
1471-6577
- Publication type
Article