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- Title
Novel TFG–RET fusion in a spindle cell tumour with S100 and CD34 coexpresssion.
- Authors
Loong, Shihleone; Lian, Derrick W Q; Kuick, Chik H; Lim, Tse H; Nah, Shireen A; Wong, Kenneth P L; Chang, Kenneth T E
- Abstract
I Sir i : The classification of spindle cell tumours with monomorphic morphology and lacking a clear immunophenotype remains challenging. The identification of the I TFG i - I RET i chimeric tyrosine kinase gene in this group of spindle cell tumours coexpressing CD34 and S100 adds I RET i to a list of oncogenic tyrosine kinase genes, i.e. I RAF1 i , I BRAF i , and I NTRK1 i / I 2 i , in the pathogenesis of this tumour type. Spindle cell tumors with RET gene fusions exhibit a morphologic spectrum akin to tumors with NTRK gene fusions.
- Subjects
CELL fusion; ANAPLASTIC lymphoma kinase; TUMORS; NON-small-cell lung carcinoma
- Publication
Histopathology, 2020, Vol 76, Issue 1, p333
- ISSN
0309-0167
- Publication type
Article
- DOI
10.1111/his.13971