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- Title
Antimicrobial peptides: a new class of antimalarial drugs?
- Authors
Vale, Nuno; Aguiar, Luísa; Gomes, Paula; Franco, Octavio Luiz; Rivas, Luis
- Abstract
A range of antimicrobial peptides (AMP) exhibit activity on malaria parasites, Plasmodium spp., in their blood or mosquito stages, or both. These peptides include a diverse array of both natural and synthetic molecules varying greatly in size, charge, hydrophobicity, and secondary structure features. Along with an overview of relevant literature reports regarding AMP that display antiplasmodial activity, this review makes a few considerations about those molecules as a potential new class of antimalarial drugs.
- Subjects
ANTIMICROBIAL peptides; PLASMODIUM; ANTIMALARIALS; HYDROPHOBIC interactions; MOSQUITOES
- Publication
Frontiers in Pharmacology, 2014, Vol 5, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2014.00275