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- Title
High-resolution HLA typing by sequencing for HLA-A, -B, -C, -DR, -DQ in 122 unrelated cord blood/patient pair transplants hardly improves long-term clinical outcome.
- Authors
Kögler, G.; Enczmann, J.; Rocha, V.; Gluckman, E.; Wernet, P.
- Abstract
Summary:To determine the impact of high-resolution (HR) HLA typing with outcomes after UCBT, DNAs of 122 pairs were analysed for HLA class I and class II mismatches (MM) based on HR typing. For HLA-A, -B on low-resolution typing and -DRB1 on HR typing, the following MM situation resulted: no MM (13%), one MM (40%), two MM (36%), three MM (8%), four MM (3%). For A, B, C, DR and DQ based on HR typing the following MM occurred: No MM (4%), one MM (10%), two MM (15%), three MM (22%), four MM (25%), five MM (12%), six MM (6%), seven MM (3%), eight MM (2%). There was no significant association between number of MM (HR) for both HLA-A, -B and -DRB1 and HLA-A, -B, -C, -DRB1 and DQB1 and aGvHD grade II–IV. There was a trend that MM in class I HR were associated with neutrophil recovery; HLA-A locus typing analysed in HvG direction was associated with reduced cumulative incidence of engraftment (P=0.04), the same for C-KIR in HvG direction (P=0.01). No significant correlation was found between numbers of HLA-MM on the HR level with 2-year survival. The analysis shows that the degree of mismatching in UCBT is even higher than expected.Bone Marrow Transplantation (2005) 36, 1033–1041. doi:10.1038/sj.bmt.1705189; published online 10 October 2005
- Subjects
CORD blood; CORD blood transplantation; STEM cells; HEMATOPOIESIS; HEMATOPOIETIC agents; BONE marrow transplantation; BONE marrow purging; BONE marrow; STEM cell transplantation
- Publication
Bone Marrow Transplantation, 2005, Vol 36, Issue 12, p1033
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1705189