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- Title
The relationship between cognitive performance and insulin resistance in non-diabetic patients with mild cognitive impairment.
- Authors
Kim, Tae‐Eun; Lee, Dong Hyun; Kim, Yoon‐Jeong; Mok, Ji Oh; Kim, Chul‐ Hee; Park, Jeong‐Ho; Lee, Tae‐Kyeong; Yoo, Kwangsun; Jeong, Yong; Lee, Yunhwan; Park, Sun Ah
- Abstract
Objective Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR. Methods This study included 85 consecutive non-diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA-IR). Cognitive performances were analyzed as a function of scores on the HOMA-IR. Results The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA-IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT-I) ( r = −0.244, p = 0.026) and Controlled Oral Word Association Test (COWAT) ( r = −0.270, p = 0.013). In subgroup analysis by APOE status, SVLT-delayed ( p = 0.027) and COWAT ( p = 0.016) scores were found to be significantly lower in the IR than the non-IR among those with APOE ε4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA-IR ( β = −0.271, t = −2.340, p = 0.022). However, IR status was identified to interact with APOE ε4 carriership toward poor performances in the COWAT ( β = −0.335, t = −2.285, p = 0.026). Conclusion This study found a domain-specific impact of HOMA-IR scores on cognitive performances in non-diabetic patients with MCI. This association was profound only in APOE ε4carriers. Copyright © 2014 John Wiley & Sons, Ltd.
- Subjects
INSULIN resistance; MILD cognitive impairment; APOLIPOPROTEIN E; COGNITION research; TYPE 2 diabetes; METABOLIC syndrome
- Publication
International Journal of Geriatric Psychiatry, 2015, Vol 30, Issue 6, p551
- ISSN
0885-6230
- Publication type
Article
- DOI
10.1002/gps.4181