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- Title
The helminth‐derived peptide, FhHDM‐1, reverses the trained phenotype of NOD bone‐marrow‐derived macrophages and regulates proinflammatory responses.
- Authors
Quinteros, Susel Loli; Snyder, Nathaniel W.; Chatoff, Adam; Ryan, Fiona; O'Brien, Bronwyn; Donnelly, Sheila
- Abstract
This article explores the concept of "trained immunity" in bone-marrow-derived macrophages and its role in the development of type 1 diabetes. The study focuses on macrophages from nonobese diabetic (NOD) mice and finds that they exhibit characteristics of trained immunity, such as increased histone methylation, glycolysis, and proinflammatory cytokine production. The authors suggest that previous infections or changes in gut microbiota may train myeloid cells in the bone marrow, leading to an amplified proinflammatory response and the initiation of autoimmunity in type 1 diabetes. The article also discusses the potential therapeutic effects of a peptide called FhHDM-1, secreted by the parasitic worm Fasciola hepatica, in preventing type 1 diabetes in mice. Administering FhHDM-1 to mice resulted in a reduction in histone methylation, a shift in macrophage metabolism, and a decrease in proinflammatory responses. These findings suggest that FhHDM-1 may alter the epigenetic imprint of macrophages, regulating immune responses and potentially preventing type 1 diabetes and other autoimmune/inflammatory disorders.
- Subjects
PEPTIDES; MACROPHAGES; PHENOTYPES; BONE marrow cells; MACROPHAGE inflammatory proteins
- Publication
European Journal of Immunology, 2024, Vol 54, Issue 6, p1
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.202350643