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- Title
Dietary energy restriction in neurological diseases: what's new?
- Authors
Zhang, Boxin; Huang, Roujie; Xu, Shaokang; He, Yuzhen; Li, Jiaxin; Wan, Lily; Xiao, Bo; Luo, Zhaohui
- Abstract
Energy-restricted diet is a specific dietary regimen, including the continuous energy-restricted diet and the intermittent energy-restricted diet. It has been proven effective not only to reduce weight and extend the lifespan in animal models, but also to regulate the development and progression of various neurological diseases such as epilepsy, cerebrovascular diseases (stroke), neurodegenerative disorders (Alzheimer's disease and Parkinson's disease) and autoimmune diseases (multiple sclerosis). However, the mechanism in this field is still not clear and a systematic neurological summary is still missing. In this review, we first give a brief summary of the definition and mainstream strategies of energy restrictions. We then review evidence about the effects of energy-restricted diet from both animal models and human trials, and update the current understanding of mechanisms underlying the biological role of energy-restricted diet in the fight against neurological diseases. Our review thus contributes to the modification of dietary regimen and the search for special diet mimics.
- Subjects
NEUROLOGICAL disorder prevention; DIET in disease; BIOLOGICAL models; REGULATION of body weight; CLINICAL trials; NEUROLOGICAL disorders; FOOD consumption; AUTOIMMUNE diseases; DIET therapy; TERMS &; phrases; LONGEVITY; NEURODEGENERATION; DISEASE risk factors
- Publication
European Journal of Nutrition, 2023, Vol 62, Issue 2, p573
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-022-03036-1