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- Title
Effects of post-acute COVID-19 syndrome on the functional brain networks of non-hospitalized individuals.
- Authors
Churchill, Nathan W.; Roudaia, Eugenie; Chen, J. Jean; Gilboa, Asaf; Sekuler, Allison; Xiang Ji; Fuqiang Gao; Zhongmin Lin; Jegatheesan, Aravinthan; Masellis, Mario; Goubran, Maged; Rabin, Jennifer S.; Lam, Benjamin; Cheng, Ivy; Fowler, Robert; Heyn, Chris; Black, Sandra E.; MacIntosh, Bradley J.; Graham, Simon J.; Schweizer, Tom A.
- Abstract
Introduction: The long-term impact of COVID-19 on brain function remains poorly understood, despite growing concern surrounding post-acute COVID-19 syndrome (PACS). The goal of this cross-sectional, observational study was to determine whether there are significant alterations in resting brain function among non-hospitalized individuals with PACS, compared to symptomatic individuals with non-COVID infection. Methods: Data were collected for 51 individuals who tested positive for COVID-19 (mean age 41±12 yrs., 34 female) and 15 controls who had cold and flu-like symptoms but tested negative for COVID-19 (mean age 41±14 yrs., 9 female), with both groups assessed an average of 4-5 months after COVID testing. None of the participants had prior neurologic, psychiatric, or cardiovascular illness. Resting brain function was assessed via functional magnetic resonance imaging (fMRI), and self-reported symptoms were recorded. Results: Individuals with COVID-19 had lower temporal and subcortical functional connectivity relative to controls. A greater number of ongoing post-COVID symptoms was also associated with altered functional connectivity between temporal, parietal, occipital and subcortical regions. Discussion: These results provide preliminary evidence that patterns of functional connectivity distinguish PACS from non-COVID infection and correlate with the severity of clinical outcome, providing novel insights into this highly prevalent disorder.
- Subjects
POST-acute COVID-19 syndrome; LARGE-scale brain networks; FUNCTIONAL magnetic resonance imaging; COVID-19 testing; FUNCTIONAL connectivity
- Publication
Frontiers in Neurology, 2023, Vol 14, p1
- ISSN
1664-2295
- Publication type
Article
- DOI
10.3389/fneur.2023.1136408