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- Title
Effect of moderate changes in dietary fatty acid profile on postprandial lipaemia, haemostatic and related CVD risk factors in healthy men.
- Authors
Poppitt, S. D.; Keogh, G. F.; Mulvey, T. B.; Phillips, A.; McArdle, B. H.; MacGibbon, A. K. H.; Cooper, G. J. S.
- Abstract
To investigate the effect of moderate changes in dietary fatty acid profile on postprandial risk factors for cardiovascular disease (CVD). Double-blind, randomised, crossover, intervention trial. University of Auckland Human Nutrition Unit, New Zealand. A total of 18 lean healthy men. A dairy butter fat modified to reduce the saturated:unsaturated fatty acid ratio and a conventional high saturated butter fat were given on two separate occasions as a high-fat test meal (59±4 g fat; 71 en% fat) at breakfast. A fat exclusion lunch, dinner and snacks were also given. Blood samples were collected at 0 (baseline), 1, 3, 6, 10 and 24 h. Maximum peak in total triacylglycerol (TAG) occurred 3 h postprandially and was highest on modified treatment (diet, P<0.05) due predominantly to increased TAG within the chylomicron-rich fraction. Transient peaks in total-, LDL- and HDL- cholesterol occurred postprandially, but did not differ between dietary treatments (P>0.05). There were no differential effects of diet on postprandial free fatty acids, apo A, apo B, glucose, insulin, amylin or haemostatic clotting factors (P>0.05). In a group of healthy young men, replacement of 16% of total saturated fatty acids by mono- and polyunsaturated fats within a dairy lipid did not induce postprandial changes in CVD risk that may be considered beneficial for health. Fonterra, Wellington; New Zealand.
- Subjects
NEW Zealand; FATTY acids; CARDIOVASCULAR diseases; DIET therapy; HIGH density lipoproteins; LIPOPROTEINS; CLINICAL trials
- Publication
European Journal of Clinical Nutrition, 2004, Vol 58, Issue 5, p819
- ISSN
0954-3007
- Publication type
Article
- DOI
10.1038/sj.ejcn.1601882